We are a research group in the Pathology and Laboratory Medicine and Human Genetics Depts. in the David Geffen School of Medicine at UCLA that does research in computational genetics and bioinformatics. We are also affiliated with the interdepartmental Bioinformatics program and the Jonsson Comprehensive Cancer Center at UCLA
We are interested in developing computational and statistical methods for understanding the genetic architecture of common human diseases. We are particularly interested in methods that leverage the genetic diversity across and within populations for large scale studies. For more details please see our research projects and publications.
- Nature Genetics highlights on our fine-mapping framework PAINTOR
- Most heritability for 11 common diseases is localized into regulatory regions (Gusev et al AJHG 2014). Congrats Sasha et al!
- Heritability of local ancestry gives insights into heritability of complex traits online at Nature Genetics.. Congrats Noah et al!
- Wen-Yun’s work on localizing ancestors using genetic data is online at Genes|Genomes|Genetics..
- PAINTOR software for fine-mapping with ENCODE functional data can be found here. Paper is online at Plos Genetics.
- Software for imputation from summary association statistics is available for download. We also provide imputed association statistics for 4 lipids phenotypes analyzed by Teslovich et al.
- We are recruiting talented postdocs/students interested in developing computational and statistical methods for medical genetics! See here how to apply.