where is a parameter that governs the overall similarity between and , the contribution of SNP to the variations of the phenotype – a large suggests that SNP contributes little to the variation of the phenotype, and a small implies significant contribution. By examining the magnitude of the hyperparameters, one can infer whether a genetic loci contribute significantly to the trait.
We regularly post new content, see more below:
Insights from ‘zooming in’ to look at Local Genetics Correlation using Summary Statistics (ρ-HESS) by Robert Smith, Huwenbo Shi, and Nick Mancuso, February 8th, 2018; based on paper: Shi H., Mancuso N., Spendlove S., Pasaniuc B. Local genetic correlation gives insights into the shared genetic architecture of complex traits
Visualizing fine-mapping studies with CANVIS, by Ruth Johnson, January 25th, 2018
Tips for Formatting A Lot of GWAS Summary Association Statistics Data, by Huwenbo Shi, February 2nd, 2018